Job summary
- Main area
- Research
- Grade
- NHS Medical & Dental: Clinical Research Fellow
- Contract
- 12 months (Fixed Term)
- Hours
- Full time - 40 hours per week (Out of hours including nights)
- Job ref
- 196-MED5263
- Employer
- Guy's and St Thomas' NHS Foundation Trust
- Employer type
- NHS
- Site
- Guys Hospital
- Town
- London
- Salary
- £54,499 per annum pro rata excl. L/Z
- Salary period
- Yearly
- Closing
- 17/08/2026 23:59
Employer heading
Clinical Research Fellow
NHS Medical & Dental: Clinical Research Fellow
Guy’s and St Thomas’ is among the UK’s busiest and most successful NHS foundation trusts. We provide a full range of hospital and community services for people in south London and as well as specialist care for patients from further afield including cancer, renal, orthopaedic, respiratory and cardiovascular services.
Guy’s is home to the largest dental school in Europe and a £160 million Cancer Centre opened in 2016. As part of our commitment to provide care closer to home, in 2017 we also opened a cancer centre and a kidney treatment centre at Queen Mary’s Hospital in Sidcup. St Thomas’ has one of the largest critical care units in the UK and one of the busiest emergency departments in London. It is also home to Evelina London Children’s Hospital.
Evelina London cares for local children in Lambeth and Southwark and provides specialist services across south east England including cardiac, renal and critical care services. We lead a number of specialist service networks aiming to ensure children are treated locally where possible, but have access to specialist expertise when they need it. Our community services include health visiting, school nursing and support for families of children with long-term conditions.
Our adult community services teams deliver care at the heart of the local communities we serve, working in partnership with GPs, local authorities and other healthcare and voluntary sector organisations. Working with our partners in Lambeth and Southwark, we are focusing on new ways of working to improve care for local patients.
In February 2021 the Royal Brompton and Harefield joined Guy’s and St Thomas’ NHS Foundation Trust, bringing together world-leading expertise in the care and research of heart and lung disease. Our merger provides a once in a generation opportunity to build a lasting, world-renowned heart and lung centre, providing the highest quality care for patients and conducting world-leading research.
We have a reputation for clinical excellence and high quality teaching and research. We are part of King’s Health Partners, one of eight accredited UK academic health sciences centres. In partnership with King’s College London we have dedicated clinical research facilities including an MHRA accredited Phase I clinical trials unit.
Patients are at the heart of everything we do and we pride ourselves on ensuring the best possible patient experience as well as safe, high quality care. We are proud to have one of the lowest mortality rates in the NHS. Following a comprehensive Care Quality Commission (CQC) inspection in 2019 we maintained our overall rating of ‘good’. Our adult community services achieved a rating of ‘outstanding’.
The commitment of our 23,500 staff is key to our success. We are one of the largest local employers and we aim to develop and support all our staff so they are able to deliver high quality, safe and efficient care. The 2019 NHS staff survey results show that we have one of the most engaged and motivated workforces in the NHS. We know this has a positive impact on the care provided to our patients.
We have one of the most ambitious capital investment programmes anywhere in the NHS.
Job overview
The post holder will be responsible for oversight and leading of Early phase and Oncology clinical research trials within the Clinical Research Facility . This will involve the use of a novel and advanced drugs and devices. You will work as part of and be supported by a multi-disciplinary research team with a strong track record of producing high quality research outcomes.
The post will be based at Guys Hospital, in the phase 1 MHRA accredited Clinical Research Facility. However, it is a requirement that you be prepared to work at any additional or different location owned or served by the Trust, either on an on-going or temporary basis according to the demands of the service.
Main duties of the job
You will coordinate and lead research projects as a sub-investigator, recruit and follow up patients according to trial protocols, collect and analyse clinical data, maintain trial documentation, and contribute to publications and presentations. The role also includes participation in specialist clinics and close collaboration with principal investigators and wider research teams. You will be responsible for over seeing the delivery of clinical trial IMP and for the safety of participants recruited to trials.
Working for our organisation
The Phase 1 MHRA clinical research facility is one only two NHS based Clinical research facilities accredited in England. The team deliver both phase 1 and advanced investigational therapies across the various specialties with a high proportion of trials sitting within the Oncology and Haematology clinical areas. The Research facility is part of a wider Clinical research facility, with an adult unit at St Thomas providing space and support for phase 2 studies, a cardiorespiratory unit at the Royal brompton, an Imaging unit also at St Thomas and a paediatric unit at the Evelina.
Detailed job description and main responsibilities
As the CRF and Oncology Fellow the post holder will:
· Support the timely delivery of clinical studies to acceptable medical standards, in-line with the requirements of sponsors, ICH GCP, and other appropriate guidelines and regulations.
· Provide medical assessment and cover for selected early phase studies in the CRF working alongside the CRF’s senior clinical team, the OHCT early phase research team and the nurse in charge;
· In partnership with the CRF Physician and clinical staff, initiate definitive strategies to anticipate and expertly manage medical safety issues, including emergencies;
· Support aspects of subject recruitment, including pre-study medical histories, informed consent, medical examinations for ongoing studies, dosing of study medication;
· On a rota basis, provide medical cover outside of normal working hours, as determined by the nature of the studies being undertaken in the CRF at the time; This can include twilight and night shift cover.
· Accept delegated responsibility to ensure that assigned studies in the CRF are carried out safely and in compliance with the protocol;
· Be responsible for specific study-related medical decisions as agreed with the Study Principal Investigator;
· Perform clinical procedures as appropriate to the assigned study (including, but not limited to, clinical examinations or testing, insertion of intravenous lines, assessment of adverse events and management of medical emergencies);
· Ensure that patients/volunteers in assigned studies give fully informed consent in writing before commencing a study;
· Assess the eligibility status of referrals for experimental treatments, maintain and update a screening list.
· Evaluate and manage acute, sub-acute and chronic adverse drug reactions and manage acute toxicological emergencies under the supervision of the consultants or CRF physician in charge.
· Assess and interpret safety and clinical data from assigned studies, e.g. Vital signs, ECG's, laboratory tests, adverse events etc;
· Follow up and report adverse events as necessary. Communicate safety issues to the Principal Investigator for a study, the Head of Department or Designee, report Serious Adverse Events to the study sponsor in accordance with Good Clinical Practice;
· Review study documentation and complete appropriate sections of Case Report Forms;
· Ensure that all clinical activities within the CRF are conducted in accordance with approved Standard Operating Procedures (SOPs)
· Maintain accurate and accessible research records and medical notes;
· Provide medical input into integrated clinical, safety and statistical reports as requested;
· Contribute to the risk assessment and planning of risk mitigation strategies for early phase trials;
· Ensure personal Trust mandatory training is up to date and support the training of medical, nursing and ancillary staff as required;
· Any other duties as may be deemed reasonable by the CRF or the Oncology Early Phase leadership;
· Participation is expected in clinical, research delivery activities, governance and other service activities with the object of ensuring a high standard of patient care, including some overnight weekday resident responsibilities on a rotational basis.
Person specification
Qualifications and training
Essential criteria
- Full GMC Registration and hold a licence to practise in the UK
Desirable criteria
- Post CMT
- MRCP or equivalent
Clinical experience
Essential criteria
- Broad based general professional training in general medicine
- Research experience
Desirable criteria
- Experience with Oncology
Knowledge and skills
Essential criteria
- Ability to work as an effective member of a multidisciplinary team
- Capable of establishing good interpersonal relationships with patients and staff of all grades
Desirable criteria
- Understanding of clinical risk management
- Competent to work without direct supervision where appropriate
Research
Essential criteria
- Understanding of the principles and applications of clinical research
Desirable criteria
- Evidence of original research
- Publications in peer-reviewed journals
- Experience of working on complex advanced therapies trials
Management
Essential criteria
- Evidence of understanding of the role of clinical management
Desirable criteria
- Evidence of leadership in the development of clinical services
Other
Essential criteria
- Evidence of understanding of and adherence to the principles of Good Medical Practice set out by the General Medical Council
- Evidence of contribution to effective clinical audit and clinical risk management
- Excellent computer literacy (email, Microsoft Word, Excel, databases).
Desirable criteria
- Experience in clinical guideline development
Employer certification / accreditation badges
Applicant requirements
You must have appropriate UK professional registration.
This post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service.
Documents to download
Further details / informal visits contact
- Name
- Shaun Cochrane
- Job title
- Deputy Director R&D (Operations)
- Email address
- [email protected]
- Telephone number
- 0738 037 9610
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